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DNA replication of the leading and lagging strand
The helicase unzips the double-stranded DNA for replication, making a forked structure. The primase generates short strands of RNA that bind to the single-stranded DNA to initiate DNA synthesis by the DNA polymerase. This enzyme can work only in the 5' to 3' direction, so it replicates the leading strand continuously. Lagging-strand replication is discontinuous, with short Okazaki fragments being formed and later linked together.
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The decoding of information in a cell's DNA into proteins begins with a complex interaction of nucleic acids. Learn how this step inside the nucleus leads to protein synthesis in the cytoplasm.
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The main reason for the presen...
Video Solution: The main reason for the presence of both a leading and a lagging strand during DNA replication is,
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DNA polymerase can read and synthesize only in the direction of 3'-to-5'DNA polymerase can only synthesize one strand at a timeOnly one strand is available to be read at any given timeThere are not enough RNA primers to have both strands be synthesized simultaneously
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Question Details till 29/09/2022
Question | |
Chapter Name | Sample Paper 2022 |
Subject | Biology (more Questions) |
Class | 12th |
Type of Answer | Video |
Question Language | In Video - English In Text - English |
Students Watched | 500 + |
Students Liked | 0 + |
Question Video Duration | 2m55s |
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The double stranded DNA is first unzipped by an enzyme called helicase. Helicase separates the two strands of DNA, and creates the replication fork. Essentialy two single stranded DNA chains are created, both facing different directions. On the leading strand, an RNA primer is created by RNA ploymerase and DNA polymerase III will continously build that strand, since it is building the DNA chain in the same direction as helicase unzips the DNA. On the lagging strand, the DNA plymerase moves the opposite direction as helicase, thus it can only copy a small length of DNA at one time. Because of the different directions the two enzymes moves on the lagging strand, the DNA chain is only synthetised in small fragments. Hence it is called the lagging strand.