. 2016 May 23;26(10):1274-84.
doi: 10.1016/j.cub.2016.03.053. Epub 2016 May 12.
Vojtěch Vacek 2 , Zuzana Zubáčová 2 , Sebastian C Treitli 2 , Romana Petrželková 3 , Laura Eme 4 , Lukáš Novák 2 , Vojtěch Žárský 2 , Lael D Barlow 5 , Emily K Herman 5 , Petr Soukal 2 , Miluše Hroudová 6 , Pavel Doležal 2 , Courtney W Stairs 4 , Andrew J Roger 4 , Marek Eliáš 3 , Joel B Dacks 5 , Čestmír Vlček 6 , Vladimír Hampl 7
Affiliations
- PMID: 27185558
- DOI: 10.1016/j.cub.2016.03.053
Free article
A Eukaryote without a Mitochondrial Organelle
Anna Karnkowska et al. Curr Biol. 2016.
Free article
Abstract
The presence of mitochondria and related organelles in every studied eukaryote supports the view that mitochondria are essential cellular components. Here, we report the genome sequence of a microbial eukaryote, the oxymonad Monocercomonoides sp., which revealed that this organism lacks all hallmark mitochondrial proteins. Crucially, the mitochondrial iron-sulfur cluster assembly pathway, thought to be conserved in virtually all eukaryotic cells, has been replaced by a cytosolic sulfur mobilization system (SUF) acquired by lateral gene transfer from bacteria. In the context of eukaryotic phylogeny, our data suggest that Monocercomonoides is not primitively amitochondrial but has lost the mitochondrion secondarily. This is the first example of a eukaryote lacking any form of a mitochondrion, demonstrating that this organelle is not absolutely essential for the viability of a eukaryotic cell.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Comment in
Mitochondrial Evolution: Going, Going, Gone.
Burki F. Burki F. Curr Biol. 2016 May 23;26(10):R410-2. doi: 10.1016/j.cub.2016.04.032. Curr Biol. 2016. PMID: 27218846
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