Nausea, vomiting, diarrhea/loose stools, stomach pain, or pain/redness at the injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Show
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: hearing changes (such as ringing in the ears, hearing loss), persistent nausea/vomiting, severe abdominal/stomach pain, unusual weakness/tiredness, dark urine, yellowing skin/eyes, muscle weakness. Get medical help right away if any of these rare but very serious side effects occur: severe dizziness, fainting, fast/irregular heartbeat. This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain/cramping, blood/mucus in your stool. If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse. Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches/sores in your mouth, a change in vaginal discharge, or other new symptoms. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: Incidence not known
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Incidence not known
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Portions of this document last updated: Nov. 01, 2022 Copyright © 2022 IBM Watson Health. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Useful when penicillin is the most appropriate drug but cannot be used because of hypersensitivity, including:
Action Suppresses protein synthesis at the level of the 50S bacterial ribosome. Therapeutic Effect(s): Bacteriostatic action against susceptible bacteria. Spectrum:
PharmacokineticsAbsorption: Variable absorption from the duodenum after oral administration (dependent on salt form). Absorption of enteric-coated products is delayed. Minimal absorption may follow topical or ophthalmic use. Distribution: Widely distributed. Minimal CNS penetration. Crosses placenta; enters breast milk. Protein Binding: 70–80%. Metabolism and Excretion: Partially metabolized by the liver, excreted mainly unchanged in the bile; small amounts excreted unchanged in the urine. Half-life: Neonates: 2.1 hr; Adults: 1.4–2 hr. TIME/ACTION PROFILE (blood levels) ROUTEONSETPEAKDURATIONPO1 hr1–4 hr6–12 hrIVrapidend of infusion6–12 hr Contraindication/PrecautionsContraindicated in:
Use Cautiously in:
Adverse Reactions/Side EffectsCV: TORSADES DE POINTES, VENTRICULAR ARRHYTHMIAS, QT interval prolongation Derm: rash EENT: ototoxicity GI: CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), nausea, vomiting, abdominal pain, cramping, diarrhea, hepatitis, infantile hypertrophic pyloric stenosis, pancreatitis (rare) GU: interstitial nephritis Local: phlebitis at iv site Neuro: seizures (rare) Misc: HYPERSENSITIVITY REACTIONS (including anaphylaxis) * CAPITALS indicate life-threatening. InteractionsDrug-Drug
Route/Dosage250 mg of erythromycin base or stearate = 400 mg of erythromycin ethylsuccinate Most Infections PO (Adults): Base, stearate– 250 mg every 6 hr, or 333 mg every 8 hr, or 500 mg every 12 hr. Ethylsuccinate– 400 mg every 6 hr or 800 mg every 12 hr. PO (Children >1 mo): Base and ethylsuccinate– 30–50 mg/kg/day divided every 6–8 hr (max = 2 g/day as base or 3.2 g/day as ethylsuccinate). Stearate– 30–50 mg/kg/day divided every 6 hr (max = 2 g/day). PO (Neonates ): Ethylsuccinate– 20–50 mg/kg/day divided every 6–12 hr. IV (Adults): 250–500 mg (up to 1 g) every 6 hr. IV (Children >1 mo): 15–50 mg/kg/day divided every 6 hr (max = 4 g/day). Acne Topical (Adults and Children >12 yr): 2% gel, solution, or pledgets twice daily. Availability (generic available)Erythromycin Base Delayed-release capsules: 250 mg , 333 mg Delayed–release tablets: 250 mg, 333 mg, 500 mg Erythromycin Ethylsuccinate Oral suspension (fruit, cherry, orange, or banana flavor): 200 mg/5 mL, 400 mg/5 mL Tablets: 400 mg Erythromycin Lactobionate Powder for injection (requires reconstitution and dilution): 500 mg/vial, 1 g Erythromycin Stearate Film-coated tablets: 250 mg Erythromycin Topical Preparations Gel: 2% Pledgets: 2% Solution: 2% In Combination with: benzoyl peroxide (Benzamycin). See combination drugs. Assessment
Lab Test Considerations: Monitor liver function tests periodically on patients receiving high-dose, long-term therapy.
Potential Diagnoses
Implementation
IV Administration
Erythromycin Lactobionate
Patient/Family Teaching
Evaluation/Desired Outcomes
ERYTHROMYCIN† is a sample topic from the Davis's Drug Guide. To view other topics, please log in or purchase a subscription. Nursing Central is an award-winning, complete mobile solution for nurses and students. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. Complete Product Information. CitationVallerand, April Hazard., et al. "ERYTHROMYCIN†." Davis's Drug Guide, 18th ed., F.A. Davis Company, 2023. Nursing Central Redesign, nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/110750/all/ERYTHROMYCIN†. Vallerand AHA, Sanoski CAC, Quiring CC. ERYTHROMYCIN†. Davis's Drug Guide. F.A. Davis Company; 2023. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/110750/all/ERYTHROMYCIN†. Accessed December 2, 2022. Vallerand, A. H., Sanoski, C. A., & Quiring, C. (2023). ERYTHROMYCIN†. In Davis's Drug Guide (18th ed.). F.A. Davis Company. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/110750/all/ERYTHROMYCIN† Vallerand AHA, Sanoski CAC, Quiring CC. ERYTHROMYCIN† [Internet]. In: Davis's Drug Guide. F.A. Davis Company; 2023. [cited 2022 December 02]. Available from: https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/110750/all/ERYTHROMYCIN†. * Article titles in AMA citation format should be in sentence-case CopyDownloadTY - ELEC T1 - ERYTHROMYCIN† ID - 110750 A1 - Sanoski,Cynthia A, AU - Vallerand,April Hazard, AU - Quiring,Courtney, BT - Davis's Drug Guide UR - https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/110750/all/ERYTHROMYCIN† PB - F.A. Davis Company ET - 18 DB - Nursing Central Redesign DP - Unbound Medicine ER - What should be monitored when taking erythromycin?Erythromycin causes common adverse drug reactions such as nausea, vomiting, diarrhea, and serious adverse drug reactions such as QT prolongation and pseudomembranous colitis. The clinician who is prescribing erythromycin should monitor the patient for QT prolongation.
What are the nursing consideration for erythromycin?Nursing considerations
Observe for signs of adverse effects eg. diarrhoea, vomiting, allergic reactions. Observe IV site closely for extravasation during infusion of drug. Observe for signs of renal, hepatic and haematological dysfunction during prolonged therapy.
What is the most common adverse effect of erythromycin?Erythromycin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer.
What should you avoid when taking erythromycin?Cautions with other medicines. antihistamine medicines, such as astemizole, terfenadine or mizolastine.. domperidone, an anti-sickness medicine.. medicines for mental health problems called pimozide or amisulpride.. migraine medicines called ergotamine or dihrydroergotamine.. simvastatin, a cholesterol-lowering medicine.. |