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Short-term outcomes of phosphodiesterase type 5 inhibitors for fetal growth restriction: a study protocol for a systematic review with individual participant data meta-analysis, aggregate meta-analysis, and trial sequential analysis

Early onset fetal growth restriction secondary to placental insufficiency can lead to severe maternal and neonatal morbidity and mortality. Pre-clinical studies and a few small randomised clinical trials have ...

Authors: Jessica Liauw, Katie Groom, Wessel Ganzevoort, Christian Gluud, Christopher J. D. McKinlay, Andrew Sharp, Laura Mackay, Chirag Kariya, Ken Lim, Peter von Dadelszen, Jacqueline Limpens and Janus C. Jakobsen

Citation: Systematic Reviews 2021 10:305

Content type: Protocol

Published on: 3 December 2021

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Systematic review and meta-analysis of the safety of chloroquine and hydroxychloroquine from randomized controlled trials on malarial and non-malarial conditions

Despite the expectations regarding the effectiveness of chloroquine (CQ) and hydroxychloroquine (HCQ) for coronavirus disease (COVID-19) management, concerns about their adverse events have remained.

Authors: Mayra Souza Botelho, Fernanda Bolfi, Renata Giacomini Occhiuto Ferreira Leite, Mauro Salles Ferreira Leite, Luisa Rocco Banzato, Luiza Teixeira Soares, Thaina Oliveira Felicio Olivatti, Amanda Sampaio Mangolim, Flávia Ramos Kazan Oliveira, Luciana Patrícia Fernandes Abbade, Joelcio Francisco Abbade, Ricardo Augusto Monteiro de Barros Almeida, Julia Simões Corrêa Galendi, Lehana Thabane and Vania dos Santos Nunes-Nogueira

Citation: Systematic Reviews 2021 10:294

Content type: Research

Published on: 4 November 2021

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