. 2016 May 23;26(10):1274-84. doi: 10.1016/j.cub.2016.03.053. Epub 2016 May 12. Vojtěch Vacek 2 , Zuzana
Zubáčová 2 , Sebastian C Treitli 2 , Romana Petrželková 3
, Laura Eme 4
, Lukáš Novák 2
, Vojtěch Žárský 2 , Lael D Barlow 5 , Emily K Herman 5 , Petr Soukal 2 , Miluše
Hroudová 6 , Pavel
Doležal 2 , Courtney W Stairs 4 , Andrew J Roger 4 , Marek Eliáš 3 , Joel B Dacks 5 , Čestmír Vlček 6
, Vladimír Hampl 7 Affiliations - PMID: 27185558
- DOI:
10.1016/j.cub.2016.03.053
Free article A Eukaryote without a Mitochondrial Organelle Anna Karnkowska et al. Curr Biol.
2016. Free article
Abstract The presence of mitochondria and related organelles in every studied eukaryote supports the view that mitochondria are essential cellular components. Here, we report the genome sequence of a microbial eukaryote, the oxymonad Monocercomonoides sp., which revealed that this organism lacks all hallmark mitochondrial proteins. Crucially, the mitochondrial iron-sulfur cluster assembly pathway, thought to be conserved in virtually all eukaryotic
cells, has been replaced by a cytosolic sulfur mobilization system (SUF) acquired by lateral gene transfer from bacteria. In the context of eukaryotic phylogeny, our data suggest that Monocercomonoides is not primitively amitochondrial but has lost the mitochondrion secondarily. This is the first example of a eukaryote lacking any form of a mitochondrion, demonstrating that this organelle is not absolutely essential for the viability of a eukaryotic cell. Copyright ©
2016 Elsevier Ltd. All rights reserved. Mitochondrial Evolution: Going, Going, Gone. Burki F. Burki F. Curr Biol. 2016 May 23;26(10):R410-2. doi:
10.1016/j.cub.2016.04.032. Curr Biol. 2016. PMID: 27218846
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Monocercomonoides isn't a living fossil, a holdout from the days of the earliest eukaryotes, Karnkowska notes. Its closest relatives still have small mitochondria, suggesting that it jettisoned the organelles fairly recently in evolutionary terms.
Why can Monocercomonoides survive without mitochondria?
Monocercomonoides seems to have gotten by without mitochondria thanks to a cytosolic sulfur mobilization system (SUF) acquired from bacteria, which appears to substitute for essential mitochondrial functions.
Does a Monocercomonoides have a nucleus?
It was established by Bernard V. Travis and was first described as those with "polymastiginid flagellates having three anterior flagella and a trailing one originating at a single basal granule located in front of the anteriorly positioned nucleus, and a more or less well-defined axostyle".
What can you conclude about the Monocercomonoides?
Monocercomonoides are a genus of single-celled organisms that live as parasites in the guts of small animals. They lack mitochondria, but other evidence shows them to be most closely related to members of the excavates.
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